Apelin/APJ relieve diabetic cardiomyopathy by reducing microvascular dysfunction

Microvascular Dysfunction in Takotsubo Cardiomyopathy

Takotsubo cardiomyopathy (TC), also called stress cardiomyopathy, apical ballooning syndrome or broken heart syndrome, is a syndrome characterized by transient regional systolic dysfunction of the left ventricle (LV), mimicking myocardial infarction (MI), but in the absence of evidence of angiographic significant obstructive coronary artery disease (CAD) or acute plaque rupture. In most cases o...

Coronary microvascular dysfunction and idiopathic dilated cardiomyopathy.

There is growing evidence of the presence and relevance of coronary microvascular abnormalities in many cardiac diseases. In particular, it has been recently shown that dilated cardiomyopathy (DCM) is characterized by dysfunction of the coronary microvessels since its very early onset. Coronary microcirculatory dysfunction is not an effect of myocardial damage but seems in turn to cause progres...

Microvascular Complications in Diabetic Erectile Dysfunction

Advances in the management of erectile dysfunction (ED) and its adverse effects on the quality of life of men and their partners have encouraged researchers to look for new solutions for treating and curing ED. The introduction of phosphodiesterase type 5 inhibitors to treat ED in 1998 was revolutionary in that it heralded the onset of a new era of effective and safe treatment for restoring mal...

Cardiac dysfunction is attenuated by ginkgolide B via reducing oxidative stress and fibrosis in diabetic rats

Objective(s): Diabetic cardiomyopathy is a leading factor of high morbidity and mortality in diabetic patients. Our previous results revealed that ginkgolide B alleviates endothelial dysfunction in diabetic rats. This study aimed to investigate the effect of ginkgolide B on cardiac dysfunction and its mechanism in diabetic rats.Materials and Methods:<...

Angiotensin 1-7 Ameliorates Diabetic Cardiomyopathy and Diastolic Dysfunction in db/db Mice by Reducing Lipotoxicity and Inflammation Mori et al: Angiotensin 1-7 Ameliorates Diabetic Cardiomyopathy